AMPDs wound healing

The burden of bacterial wound infections has increased significantly due to antibiotic resistance to most currently available antimicrobial drugs. Within this project, a new chemical platform for coupling chitosan derivatives to antimicrobial peptide dendrimers (AMPDs) has been developed.

The AMPD-chitosan conjugates act synergistically to destroy bacteria, without any loss of antimicrobial activity. These new proprietary “active principles” were successfully incorporated into various biopolymer-based formulations, including nanoparticles, gels, and foams.

In vivo studies conducted in both healthy and infected murine models demonstrated the potent antibacterial performance of the developed dressings. This versatile chemical technology platform provides a promising foundation for the design of new membrane-disruptive therapeutics aimed at eliminating pathogens associated with acute and chronic wounds.