Publications

2023¶

• Vérièpe-Salerno, J., Podavini, S., Long, M.J.C., Kolotuev, I., Cuendet, M., Thome, M. (2023) MALT-1 shortens lifespan by inhibiting autophagy in the intestine of C. elegans. Autophagy Reports, 2:2277584.
• Sevik Kilicaslan, O., Cretton, S., Hausmann, E., Quirós-Guerrero, L., Karimou, S., Kaiser, M., Mäser, P., Christen, P., Cuendet, M. (2023) Antiprotozoal activity of natural products from Nigerien plants used in folk medicine. Frontiers in Pharmacology, 14:1190241.
• Spaleniak, W., Cuendet, M. (2023) Resveratrol as a circadian clock modulator: mechanisms of action and therapeutic applications. Molecular Biology Reports, 50, 6159-70.
• Ferro, A., Pantazaka, E., Athanassopoulos, C.M., Cuendet, M. (2023) Histone deacetylase-based dual targeted inhibition in multiple myeloma. Medicinal Research Reviews, 43, 2177–36.
• Saraux, N., Bruna, L., Ebrahimi, S. N., Karimou, S., Christen, P., Cuendet, M. (2023) Antiproliferative activity of compounds isolated from the root bark of Lannea acida in multiple myeloma cell lines. Phytochemistry, 209, 113641.
• Ferro, A., Graikioti, D., Gezer, E., Athanassopoulos, C.M., Cuendet, M. (2023) Entinostat-bortezomib hybrids against multiple myeloma. Molecules, 28, 1456

2022¶

• Saraux, N., Cretton, S., Sevik Kilicaslan, O., Occioni, C., Ferro, A., Quiros-Guerrero, L., Karimou, S., Christen, P., Cuendet, M. (2022) Isolation and structure elucidation of compounds from Sesamum alatum and their antiproliferative activity against multiple myeloma cells. Journal of Natural Products, 85, 2706-2713.
• Ferro, A., Cretton, S., Venturini Polese, A. A., Coutinho Endringer, D., Cuendet, M. (2022) Active compounds from Inga edulis Martius seeds against multiple myeloma. Natural Product Communications, 17, 1.
• Wong, C.Y., Cuendet, M., Spaleniak, W., Gholizadeh, H., Marasini, N., Ong, H.X., Traini, D. (2022) Validation of a cell integrated next generation impactor to assess in vitro drug transport of physiologically relevant aerosolized particles. International Journal of Pharmaceutics, 624, 122024.
• Coira, I.F., Rincón, R., Cuendet, M. (2022) The multiple myeloma landscape: epigenetics and non-coding RNAs. Cancers, 14, 2348.
• Sevik Kilicaslan, O., Cretton, S., Quiros-Guerrero, L., Bella, M.A., Kaiser, M., Mäser, P, Ndongo, J.T., Cuendet, M. (2022) Isolation and structural elucidation of compounds from Pleiocarpa bicarpellata and their in vitro antiprotozoal activity. Molecules, 27, 2200.
• Saraux, N., Imeri, D., Quiros-Guerrero, L., Karimou, S., Christen, P., Cuendet, M. (2022) Phytochemical investigation of the roots of Ipomoea asarifolia and antiproliferative activity of the isolated compounds against multiple myeloma cells. Journal of Natural Products, 85, 56-62

2021¶

• Freitas Misakyan, M. F. F._,_Wijeratne, E.M.K., Issa, M.E., Xu, Y.M., Monteillier, A., Gunatilaka, A.A.L., Cuendet, M. (2021) Structure-activity relationships of withanolides as anti-proliferative agents for multiple myeloma: Comparison of activity in 2D models and a 3D co-culture model. Journal of Natural Products, 84, 2321-2335.
• Cretton, S., Genta-Jouve, G., Munoz, O., Buergi, T., Kaiser, M., Mäser, P., Cuendet, M., Christen, P. (2021) Hygroline derivatives from Schizanthus tricolor and their anti-trypanosomatid and antiplasmodial activities. Phytochemistry, 192, 112957.
• Berndt, S., Carpentier, G., Turzi, A., Borlat, F., Cuendet, M., Bodaressi, A. (2021) Angiogenesis is differentially modulated by platele-derived products. Biomedicines, 9, 251

2020¶

• Lacombe, J., Cretignier, T., Meli, L., Wijeratne, K., Veuthey, J.-L., Cuendet, M., Gunatilaka, A.A.L., Zenhausern, F. (2020) Withanolide D enhances radiosensitivity of human cancer cells by inhibiting DNA damage non-homologous end joining repair pathway. Frontiers in Oncology, 9, 1468

2019¶

• Freitas, M., Issa, M.E., Cuendet, M. (2019) Targeting the resistance in multiple myeloma. Proceedings, 11, 3.
• Ahoua, A.R.C., Monteillier, A., Borlat, F., Ciclet, O., Marcourt, L., Nejad Ebrahimi, S., Koné, M.W., Bonfoh, B., Christen, P., Cuendet, M. (2019) Anti-inflammatory and quinone reductase-inducing compounds from Beilschmiedia mannii. Planta Medica, 85, 379-384

2018¶

• Monteillier, A., Voisin, A., Furrer, P., Allémann, E., Cuendet, M. (2018) Intranasal administration of resveratrol successfully prevents lung cancer in A/J mice, Scientific Reports, 8, 14257.
• Ben Bakrim, W., El Bouzidi, L., Nuzillard, J.-M., Cretton, S., Saraux, N., Monteillier, A., Christen, Ph., Cuendet, M., Bekkouche, K. (2018) Bioactive metabolites from the leaves of Withania adpressa, Pharmaceutical Biology, 56, 505-510 (2018).
• Queiroz, M.M.F., Monteillier, A., Berndt, S., Marcourt, L., de Souza Franco, E., Carpentier, G., Ebrahimi, S.N., Cuendet, M., Bolzani, V., Maia, M.B.S., Queiroz, E.F., Wolfender, J.-L. (2018) NF-κB and angiogenesis inhibitors from the aerial parts of Chresta martii, Journal of Natural Products, 81, 1769-1776.
• Vidakovic, M., Marinello, J., Lahtela-Kakkonen, M., Matulis, D., Linkumiene, V., Michel, B.Y., Navakauskiene, R., Christodoulou, M.S., Passarella, D., Klimasauskas, S., Blanquart, C., Cuendet, M., Ovadi, J., Poulain, S., Fontaine-Vive, F., Burger, A., Martinet, N. (2018) Natural compound epigenetic activities, OBM Genetics, (in press).
• Cretton, S., Saraux, N., Monteillier, A., Righi, D., Marcourt, L., Genta-Jouve, G., Wolfender, J.-L., Cuendet, M., Christen, Ph. (2018) Anti-inflammatory and antiproliferative diterpenoids from Plectranthus scutellarioides, Phytochemistry, 154, 39-46.
• Ndongo, J.T., Mbing, J.N., Monteillier, A., Tala, M.F., Rütten, M., Mombers, D., Cuendet, M., Pegnyemb, D.E., Dittrich, B., Laatsch, H. (2018) Carbazole-, aspidofractinine-, and aspidocarpamine-type alkaloids from Pleiocarpa pycnantha, Journal of Natural Products, 81, 1193-1202.
• Faria Freitas, M., Cuendet, M., Bertrand, P. (2018) HDAC inhibitors: a 2013-2017 patent survey, Expert Opinion on Therapeutic Patents, 28, 365-381.
• Monteillier, A., Allard, P.-M., Gindro, K., Wolfender, J.-L., Cuendet, M. (2018) Lung cancer chemopreventive activity of patulin isolated from Penicillium vulpinum, Molecules, 23, 636
• Berndt, S., Issa, M.E., Carpentier, G., Cuendet, M. (2018) A bivalent role of genistein in sprouting angiogenesis, Planta Medica, 84, 1-10.
• Cretton, S., Oyarzún, A., Righi, D., Sahib, L., Kaiser, M., Christen, P., Fajardo, V. (2018) A new antifungal and antiprotozoal bibenzyl derivative from Gavilea lutea, Natural Product Research, 32, 695-701_._

2017¶

• Ndongo, J.T., Ngo Mbing, J., Tala, M.F., Monteillier, A., Pegnyemb, D.E., Cuendet, M., Laatsch, H. (2017) Indoline alkaloids from Tabernaemontana contorta with cancer chemopreventive activity, Phytochemistry, 144, 189-196.
• Issa, M.E., Wijeratne, E.M.K., Gunatilaka, A.A.L., Cuendet, M. (2017) Withanolide D exhibits similar cytostatic effect in drug-resistant and drug-sensitive multiple myeloma cells, Frontiers in Pharmacology, 8, 610.
• Pu, W.L., Sun L.K., Gao, X.M., Rüegg, C., Cuendet, M., Hottiger, M.O., Kun, Z., Miao, L., Zhang, Y.S., Gebauer, C. (2017) Targeting tumor-associated macrophages by anti-tumor Chinese Materia Medica, Chinese Journal of Integrative Medicine, 23, 723-732.
• Traoré, M., Zwick, V., Simões-Pires, C., Nurisso, A., Issa, M., Cuendet, M., Maynadier, M., Wein, S., Vial, H., Jamet, H., Wong, Y.-S. (2017) Hydroxyl ketone-based histone deacetylase inhibitors to gain insight into class I HDAC selectivity versus that of HDAC6, ACS Omega, 2, 1550-1562.
• Klein-Júnior, L.C., Cretton, S., Allard, P.M., Genta-Jouve, G.,  Passos, C.S., Salton, J., Bertelli, P., Pupier, M., Jeannerat, D., Vander Heyden, Y., Gasper, A.L., Wolfender, J.-L., Christen, P., Henriques, A.T. (2017) Targeted isolation of monoterpene indole alkaloids from Palicourea sessilis, Journal of Natural Products, 80, 3032-3037.
• Issa, M.E., Cretton, S., Cuendet, M. (2017) Targeting multiple myeloma cancer stem cells with natural products – lessons from other hematological malignancies, Planta Medica, 83, 752-760.
• Simoes-Pires, C., Zwick, V., Cretton, S., Cuendet, M. (2017) Simultaneous measurement of HDAC1 and HDAC6 activity in HeLa cells using UHPLC-MS, Journal of Visualized Experiments, 126, e55878.
• Monteillier, A., Cretton, S., Ciclet, O., Marcourt, L., Ebrahimi, S., Christen, Ph., Cuendet, M. (2017) Cancer chemopreventive activity of compounds isolated from Waltheria indica, Journal of Ethnopharmacology, 203, 214-225.
• Issa, M.E., Sedigheh Takhasha, F., Sekhar Chirumamilla, C., Perez-Novo, C., Vanden Berghe, W., Cuendet, M. (2017) Epigenetic strategies to reverse drug resistance in heterogeneous multiple myeloma, Clinical Epigenetics, 9, 17.
• Francisco Hilario, F., Traoré, M., Zwick, V., Berry, L., Simões-Pires, C., Cuendet, M., Fantozzi, N., Pereira de Freitas, R., Maynadier, M,. Wein, S., Vial, H., Wong, Y.-S. (2017) Synthesis of an uncharged tetra-cyclopeptide acting as transmembrane carrier: enhanced cellular and nuclear uptake, Organic Letters, 19, 612-615.
• Simoes-Pires, C., Bertrand, P., Cuendet, M. (2017) Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137), Expert Opinion on Therapeutic Patents, 27, 229-236.
• Issa, M.E., Cuendet, M. (2017) Withaferin A induces cell death and differentiation in multiple myeloma cancer stem cells, MedChemComm, 8, 112-121.
• Cretton, S., Muñoz, O., Tapia, J., Marcourt, L., Maes, L., Christen, P. (2017) Two new hygroline and tropane alkaloids isolated from Schizanthus hookeri and S. tricolor (Solanaceae), Natural Product Communications 12, 355-358.
• Petit, C., Ceccarelli, M., Cretton S., Houriet, J., Skalicka-Woźniak, K., Christen, P., Carrupt, P.-A., Goracci, L., Wolfender, J.-L. (2017) Passive intestinal absorption of representative plant secondary metabolites: a physicochemical study, Planta Medica 83, 718-726

2016¶

• Del Rio-Sancho, S., Cros, C., Coutaz, B., Cuendet, M., Kalia, Y.N. (2016) Cutaneous iontophoresis of µ-conotoxin CnIIIC-A potent Nav1.4 antagonist with analgesic, anaesthetic and myorelaxant properties, International Journal of Pharmaceutics, 518, 59-65.
• Zwick, V., Allard, P.M., Ory, L., Simoes-Pires, C., Marcourt, L., Gindro, K., Wolfender, J.L., Cuendet, M. (2016) UHPLC/MS-based HDAC assay applied to bio-guided microfractionation of fungal extracts, Phytochemical Analysis, 28, 93-100.
• Zwick, V., Simoes-Pires, C., Nurisso, A., Petit, C., Dos Santos Passos, C., Randazzo, G.M., Martinet, N., Bertrand, P., Cuendet, M. (2016) Synthesis of a selective HDAC6 inhibitor active in neuroblasts, Bioorganic & Medicinal Chemistry Letters, 26, 4955-4959.
• Issa, M.E., Berndt, S., Carpentier, G., Pezzuto, J.M., Cuendet, M. (2016) Bruceantin inhibits multiple myeloma cancer stem cell proliferation, Cancer Biology and Therapy, 17, 966-975.
• Zwick, V., Simoes-Pires, C., Cuendet, M. (2016) Cell-based multi-substrate assay coupled to UHPLC-ESI-MS/MS for a quick identification of class-specific HDAC inhibitors, Journal of Enzyme Inhibition and Medicinal Chemistry, 31, 209-214.
• Cretton, S., Dorsaz, S., Azzollini, A., Favre-Godal, Q., Marcourt, L., Ebrahimi, S., Voinesco, F., Michellod, E., Sanglard, D., Gindro, K., Wolfender, J.-L., Cuendet, M., Christen, Ph. (2016) Antifungal quinoline alkaloids from Waltheria indica, Journal of Natural Products, 79, 300-307.
• Cincinelli, R., Zwick, V., Musso, L., Zuco, V., De Cesare, M., Zunino, F., Simoes-Pires, C., Nurisso, A., Giannini, G., Cuendet, M., Dallavalle, S. (2016) Biphenyl-4-yl-acrylohydroxamic acids: identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity, European Journal of Medicinal Chemistry, 112, 99-105.
• Bertrand, S., Azzollini, A., Nievergelt, A., Boccard, J., Rudaz, S., Cuendet, M., Wolfender, J.L. (2016) Statistical correlations between HPLC activity-based profiling results and NMR/MS microfractions data to deconvolute bioactive compounds in mixture, Molecules, 21 (3), 259.
• Sakr, O.S., Berndt, S., Carpentier, G., Cuendet, M., Jordan, O., Borchard, G. (2016) Arming Embolic Beads with Anti-VEGF Antibodies and Controlling their Release Using LbL Technology, Journal of Controlled Release, 224, 199-207.
• Zeraik, M.L., Queiroz, E.F., Marcourt, L., Ciclet, O., Castro-Gamboa, I., Silva, D. H. S., Cuendet, M., Bolzani, V., Wolfender, J.-L. (2016) Antioxidants, quinone reductase inducers and acetylcholinesterase inhibitors from Spondias tuberosa fruits, Journal of Functional Foods, 21, 396-405.
• Zwick, V., Nurisso, A., Simoes-Pires, C., Martinet, N., Lehotzky, A., Ovadi, J., Cuendet, M., Blanquart, Ch., Bertrand, Ph. (2016) Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates, Bioorganic & Medicinal Chemistry Letters, 26, 154-159.
• Petit, C., Bujard, A., Skalicka-Woźniak, K., Cretton, S., Houriet, J., Christen, P., Carrupt, P.-A., Wolfender, J.-L. (2016) Prediction of the passive intestinal absorption of medicinal plant extract constituents with the Parallel Artificial Membrane Permeability Assay (PAMPA), Planta Medica 82, 424-431.
• Kacem, N., Roumy, V., Duhal, N., Merouane, F.,Neut, C., Christen, P., Hostettmann, K., Rhouati, S. (2016) Chemical composition of the essential oil from Algerian Genista quadriflora Munby and determination of its antibacterial and antifungal activities, Industrial Crops and Products 90, 87-93.
• Nelson, R., Kesternich, V., Pérez-Fehrmann, M., Jaldi, S., Marcourt, L., Christen, P. (2016) Regiospecific synthesis of 1,4,5-trisubstituted 1,2,3-triazoles via enolate–azide cycloaddition, Journal of Chemical Research 40, 453-457

2015¶

• Musso, L., Cincinelli, R., Zuco, V., Zunino, F., Nurisso, A., Cuendet, M., Giannini, G., Vesci, L., Pisano, C., Dallavalle, S. (2015) Investigation on the ZBG-functionality of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase inhibitors, Bioorganic & Medicinal Chemistry Letters, 25, 4457-4460.
• Taibon, J., Ankli, A., Schwaiger, S., Magnenat, C., Boka, V.I., Simoes-Pires, C., Aligiannis, N., Cuendet, M., Skaltsounis, A.L., Reich, E., Stuppner, H. (2015) Prevention of false positive results: development of an HPTLC autographic assay for the detection of natural tyrosinase inhibitors, Planta Medica, 81, 1198-1204.
• Cretton, S., Breant, L., Pourrez, L., Ambuehl, Ch., Perozzo, R., Marcourt, L., Kaiser, M., Cuendet, M., Christen, Ph. (2015) Chemical constituents from Waltheria indica exert in vitro activity against Trypanosoma brucei and T. cruzi, Fitoterapia, 105, 55-60.
• Ndongo, J.T., Issa, M.E., Messi, A.N., Ngo Mbing, J., Cuendet, M., Pegnyemb, D.E., Bochet, C.G. (2015) Cytotoxic flavonoids and other constituents from the stem bark of Ochna schweinfurthiana, Natural Product Research, 2, 1-4. 
• Michel, B.Y., Cuendet M., Barthes, N.P.F., Burger, A., Bertrand, P., Martinet, N. (2015) Détection des modifications de la méthylation de l'ADN et de la chromatine, Revue Francophone des Laboratoires, 473, 55-62.
• Aquino, R., Mencherini, T., Picerno, P., Christen, P., Castro, C., Villarroel, P., Delporte, C., Muñoz, O. (2015) Antioxidant activity of selected chemical constituents of Quinchamalium chilensis, International Journal of Pharmaceutical Sciences and Nanotechnology 8, 2775-2778.
• Bieri, S., Mathon, C., Edder, P., Christen, P. (2015) Occurrence of natural hepatotoxins in herbal teas, Chimia 69, 231

2014¶

• El Bahhaj, F., Désiré, J., Blanquart, Ch., Martinet, N., Zwick, V., Simoes-Pires, C., Cuendet, M., Grégoire, M., Bertrand, Ph. (2014) Superacid and thiol-ene reactions for access to psammaplin analogues with HDAC inhibition activities, Tetrahedron, 70, 9702-9708.
• Zwick, V., Chatzivasileiou, A.-O., Deschamps, N., Roussaki, M., Simoes-Pires, C., Nurisso, A., Denis, I., Blanquart, Ch., Martinet, N., Carrupt, P.-A., Detsi, A., Cuendet, M. (2014) Aurones as histone deacetylase inhibitors: identification of key features, Bioorganic & Medicinal Chemistry Letters, 24, 5497-5501.
• Cretton, S., Breant, L., Pourrez, L., Ambuehl, Ch., Marcourt, L., Ebrahimi, S.N., Hamburger, M. Perozzo, R., Karimou, S., Kaiser, M., Cuendet, M., Christen, Ph. (2014) Antitrypanosomal quinoline alkaloids from the roots of Waltheria indica, Journal of Natural Products, 77, 2304-2311.
• Kouloura, E., Danika, E., Kim, S., Hoerlé, M., Cuendet, M., Halabalaki, M., Skaltsounis, L.A. (2014) Rapid identification of coumarins from Micromelum falcatum by UPLC-HRMS/MS and targeted isolation of three new derivatives, Molecules, 19, 15042-15057.
• Queiroz, M.M.F., Queiroz, E.F., Zeraik, M.L., Marti, G., Favre-Godal, Q., Simoes-Pires, C., Marcourt, L., Carrupt, P.-A., Cuendet, M., Paulo, M.Q., Bolzani, V.S., Wolfender, J.-L. (2014) Antifungals and acetylcholinesterase inhibitors from the stem bark of Croton heliotropiifolius, Phytochemistry Letters, 10, 88-93.
• Simoes-Pires, C., Hostettmann, K., Haouala, A., Cuendet, M., Falquet, J., Graz, B., Christen, P. (2014) Reverse pharmacology for developing an anti-malarial phytomedicine. The example of Argemone mexicana, Journal for Parasitology: Drugs and Drug Resistance, 4, 338-346.
• Queiroz, M.M., Queiroz, E., Zeraik, M., Ebrahimi, S., Marcourt, L., Cuendet, M., Gamboa, I., Hamburger, M., Bolzani, V., Wolfender, J.-L. (2014) Chemical composition of the bark of Tetrapterys mucronata and identification of acetylcholinesterase inhibitory constituents, Journal of Natural Products, 77, 650-656.
• Biloa-Messi, B., Ho, R., Meli Lannang, A., Cressend, D., Perron, K., Nkengfack, A.E., Carrupt, P.-A., Hostettmann, K., Cuendet, M. (2014) Isolation and biological activity of compounds from Garcinia preussii, Pharmaceutical Biology, 52, 706-711.
• Cretton, S., Bréant, L., Pourrez, L., Marcourt, L., Ambuehl, C., Perozzo, R., Ebrahimi, S., Hamburger, M., Karimou, S., Kaiser, M., Cuendet, M., Christen, P. (2014) Alcaloïdes quinoléiques à activité antitrypanosomale isolés des racines de Waltheria indica, Pharma Journal, 11, 11-13. 
• Cuendet, M., Nievergelt, A., Pezzuto, J.M. (2014) Molecular targets of botanicals used for chemoprevention. In Integrative Oncology. 2nd edition, Abrams, D.I., Weil, A., eds. Oxford University Press, New York, NY; pp. 52-84.
• Mathon, C., Ankli, A., Reich, E., Bieri, S., Christen, P. (2014) Screening and determination of sibutramine in adulterated herbal slimming supplements by HPTLC-UV densitometry, Food Additives & Contaminants: Part A 31, 15-20.
• Mathon, C., Ankli, A., Reich, E., Bieri, S., Christen, P. (2014) HPTLC determination of sibutramine in adulterated herbal slimming supplements. Camag Bibliography Service 112, 9-11.
• Berkov, S., Mutafova, B., Christen, P. (2014) Molecular biodiversity and recent analytical developments: a marriage of convenience, Biotechnology Advances 32, 1102-1110.
• Cretton, S., Bartholomeusz, T.A., Mehl, F., Allenbach, Y., Matheeussen, A., Cos, P., Maes, L., Christen, P., (2014) Synthesis and in vitro evaluation of tropane halogenated-derivatives against malaria, sleeping sickness, Chagas disease andleishmaniasis, Medicinal Chemistry (Bentham) 10, 753-758.
• Kacem, N, Goossens, J.-F., Duhal, N., Roumy, V., Hennebelle, T, Christen, P., Hostettmann, K., Rhouati, S. (2014) Determination of alkaloids in endemic Genista quadriflora Munby (Fabaceae), Biochemical Systematics and Ecology 56, 83-87.
• Christen, P., Mathon, C., Bieri, S. (2014) Targeted analysis of biomarkers for the screening of botanicals in herbal food supplements by LC-MS/MS, Natural Products Chemistry & Research 2, 47.
• Mathon, C., Edder, P., Bieri, S., Christen, P. (2014) Survey of pyrrolizidine alkaloids in teas and herbal teas on the Swiss market using HPLC-MS/MS, Analytical & Bioanalytical Chemistry 406, 7345-7354.
• Mathon, C., Edder, P., Christen, P., Bieri, S. (2014) Unexpected occurrence of caffeine in sleep-inducing herbal teas, Chimia 68, 705-709.
• Christen, P., Kaufmann, B. (2014) New trends in extraction of natural products: Microwave-assisted extraction and pressurized liquid extraction. In Handbook of Chemical and Biological Plant Analytical Methods. Hostettmann, K., Chen, S., Marston, A., Stuppner, H. eds., John Wiley & Sons, Ltd Chichester, UK; pp. 77-104.
• Nelson, R., Kesternich, V.,Pérez-Fehrmann, M., Salazara, F., Marcourt, L., Christen, P., Godoy, P. (2014) Synthesis and antifungal activity of phenacyl azoles, Journal of Chemical Research 38, 549-552

2013¶

• Duplan, V., Serba, C., Garcia, J., Valot, G., Barluenga, S., Hoerlé, M., Cuendet, M., Winssinger, N. (2013) Synthesis of sesquiterpene-inspired derivatives designed for covalent binding and their inhibition of the NF-κB pathway, Organic & Biomolecular Chemistry, 12, 370-375.
• Giacomelli, E., Bertrand, S., Nievergelt, A., Zwick, V., Simoes-Pires, C., Marcourt, L., Rivara-Minten, E., Cuendet, M., Bisio, A., Wolfender, J.L. (2013) Cancer chemopreventive diterpenes from Salvia corrugata, Phytochemistry, 96, 257-264.
• Simões-Pires, C., Zwick, V., Nurisso, A., Schenker, E., Carrupt, P.A., Cuendet, M. (2013) HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs? Molecular Neurodegeneration, 8, 7. Highly accessed.
• Cesari, I., Hoerlé, M., Simoes-Pires, C., Grisoli, P., Queiroz, E.F., Dacarro, C., Marcourt, L., Moundipa, P.F., Carrupt, P.A., Cuendet, M., Caccialanza, G., Wolfender, J.L., Brusotti, G. (2013) Anti-inflammatory, antimicrobial and antioxidant activities of Diospyros bipindensis (Gürke) extracts and its main constituents, Journal of Ethnopharmacology, 146, 264-270. 
• Dos Santos Passos, C., Simoes-Pires, C., Henriques, A., Cuendet, M., Carrupt, P.-A., Christen, Ph. (2013) Alkaloids as inhibitors of monoamine oxidases and their role in the central nervous system. In Studies in Natural Products Chemistry. Rahman, A.U., ed. Elsevier, Oxford, UK; Vol 43, pp. 123-144.
• Humam, M., Shoul, T., Jeannerat, D., Muñoz, O., Christen, P. (2013) Comment on the manuscript of Muñoz M.A. et al. published in Phytochemistry Letters (2012) 5: 450–454 entitled “Absolute configuration and stereochemical analysis of 3,6-dibenzoyloxytropane”, Phytochemistry Letters 6, 90.
• Mathon, C., Duret, M., Kohler, M., Edder, P., Bieri, S., Christen, P. (2013) Multi-targeted screening of botanicals in food supplements by liquid chromatography with tandem mass spectrometry, Food Chemistry 138, 709-717.
• Perez-Fehrmann, M., Kesternich, V, Verdugo, F., Marcourt, L. Christen, P., Brito, I. (2013) 1H and 13C NMR spectral assignments and X-ray crystallography of N-(3-(1H-imidazol-1-yl)propyl)-2-phenylquinazolin-4-amine**,** Journal of the Chilean Chemical Society 58, 1771-1774.
• Bayiha Ba Njock, G., Bartholomeusz, T.A., Ngono Bikobo, D., Foroozandeh, M., Shivapurkar, R., Christen, P., Pegnyemb, D.E., Jeannerat, D. (2013) Structure and dynamic of three indole alkaloids from Campylospermum genus (Ochnaceae), Helvetica Chimica Acta 96, 1298-1304.
• Mathon, C., Bongard, B., Duret, M., Ortelli, D., Christen, P., Bieri, S. (2013) Analysis of the neurotoxin anisatin in star anise by HPLC-MS/MS, Food Additives & Contaminants: Part A 30, 1598-1605.
• Muñoz, O., Maya, J.D., Ferreira, J., Christen, P., San Martin, J., Lopez- Muñoz, R., Morello, A., Kemmerling, U. (2013) Medicinal plants from Chile: Evaluation of the anti-Trypanosoma cruzi activity, Zeitschrift für Naturforschung C, 68C, 198-202.
• Morales, M.A, Ahumada, F., Castillo, E., Burgos, R, Christen, P., Bustos, V., Muñoz, O. (2013) Inhibition of cholinergic contractions of rat ileum by tropane-type alkaloids present in Schizanthus hookeri, Zeitschrift für Naturforschung C 68C, 203-209.
• Christen, P., Bieri, S., Berkov, S. (2013) Methods of analysis: tropane alkaloids from plant origin. In: Natural Products – Phytochemistry, Botany, Metabolism. Ramawat, K.G., Merillon, J.M. eds., Springer Verlag, Berlin, Ger; pp.1009-1048

2012¶

• Christen, Ph., Cuendet, M. (2012) Plants as a source of therapeutic and health products, Chimia, 66 (5), 320-323.
• Al-Massarani, S.M., Bertrand, S., Nievergelt, A., El-Shafae, A.M., Al-Howiriny, T.A., Al-Musayeib, N.M., Cuendet, M., Wolfender, J.L. (2012) Acylated pregnane glycosides from Caralluma sinaica, Phytochemistry, 79, 129-140. 
• Ho, R., Nievergelt, A., Simoes Pires, C., Cuendet, M. (2012) Histone deacetylases as cancer chemopreventive targets for natural products. In Studies in Natural Products Chemistry. Rahman, A.U., ed. Elsevier, Oxford, UK; Vol 38, pp. 247-267.
• Bayiha Ba Njock, G., Bartholomeusz, T.A., Foroozandeh, M., Pegnyemb, D.E., Christen, P., Jeannerat, D. (2012) NASCA-HMBC, a new NMR methodology for the resolution of severely overlapping signals. Application to the study of agathisflavone, Phytochemical Analysis 23, 126-130.
• Perez-Fehrmann m., Kesternich, V., Verdugo, F., Christen, P., Besnard, C. (2012) 2-(4-Bromophenyl)-N-[3-(1H-imidazol-1-yl)propyl]quinazolin-4-amine, Acta Crystallographica E E68, o2249

2011¶

• Wolfender, J.-L., Eugster, P.J., Bohni, N., Cuendet, M. (2011) Advanced methods for natural product drug discovery in the field of nutraceuticals, Chimia, 65, 400-406.
• Humam, M., Kehrli, T., Jeannerat, D., Muñoz, O., Christen, P., Hostettmann, K. (2011) Schizanthines N, O and P, tropane alkaloids from the aerial parts of Schizanthus tricolor, Journal of Natural Products 74, 50-53.
• Muñoz, O., Christen, P., Cretton, S., Backhouse, N., Torres, V., Correa, O., Costa, E., Miranda, H., Delporte, C. (2011) Chemical study and anti-inflammatory, analgesic and antioxydant activities from the leaves of Aristotelia chilensis (Mol.) Stuntz, Journal of Pharmacy and Pharmacology 63, 849-859.
• Muñoz, O., Christen, P., Cretton, A.F., Barrero A.F., Lara, A., Herrador M.M. (2011) Comparison of the essential oils of leaves and stem bark from two populations of Drimys winteri, a Chilean herbal medicine, Natural Product Communications 6, 879-882.
• Humam, M., Shoul, T., Jeannerat, D., Muñoz, O., Christen, P. (2011) Chirality and numbering of substituted tropane alkaloids, Molecules 16, 7199-7209.
• Cretton, S., Bartholomeusz T.A., Humam, M., Marcourt, L., Allenbach, Y., Jeannerat, D., Muñoz, O., Christen, P. (2011) Grahamines A-E, Cyclobutane-Centered Tropane Alkaloids from the Aerial Parts of Schizanthus grahamii, Journal of Natural Products 74, 2388-2394

2010¶

• Calamini, B., Ratia, K., Malkowski, M.G., Cuendet, M., Pezzuto, J.M., Santarsiero, B.D., Mesecar A. D. (2010) Pleiotropic mechanisms facilitated by resveratrol and its metabolites, Biochemical Journal, 429, 273-282.
• Cuendet, M., Guo, J., Zhu, D., Oteham, C.P., Nikolic, D., Moon, R.C., van Breemen, R.B., Pezzuto, J.M. (2010) Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice, Cancer Prevention Research, 3(2), 221-232.
• Cretton, S., Glauser, G., Humam, H., Jeannerat, D., Muñoz, O., Maes, L., Christen, P., Hostettman, K. (2010) Isomeric tropane alkaloids from the aerial parts of Schizanthus tricolor, Journal of Natural Products 73, 844-847.
• Bayiha Ba Njock, G., Pegnyemb, D.E., Bartholomeusz, T.A., Christen, P., Vitorge, B., Nuzillard, J.-M. Shivapurkar, R.; Foroozandeh, M., Jeannerat, D. (2010) Spectral aliasing: A super zoom for 2D-NMR spectra. Principles and applications, Chimia 64, 235-240

2009¶

• Kang, S.S., Cuendet, M., Endringer, D.C., Croy, V.L., Pezzuto, J.M., Lipton, M.A. (2009) Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-κB, Bioorganic and Medicinal Chemistry, 17 (3), 1044-1054. 
• Cuendet, M., Pezzuto, J.M. (2009) Molecular targets of botanicals used for chemoprevention. In Integrative Oncology. Abrams, D.I., Weil, A., eds. Oxford University Press, New York, NY; pp. 41-56.
• Vitorge, B., Bieri, S., Humam, M., Christen, P., Hostettmann, K., Muñoz, O., Loss, S., Jeannerat, D. (2009) High-precision heteronuclear 2D NMR experiments using 10 ppm spectral window to resolve carbon overlap, Chemical Communications 950-952.
• Abdeljebbar, L.H., Benjouad, A., Morjani, H., Merghoub, N., El Haddar, S., Humam, M., Christen, P., Hostettmann, K., Bekkouche, K., Amzazi, S. (2009) Evaluation of the cytotoxicity withanolides from Withania adpressa, Thérapie 64, 121-127.
• Christen, P., Bieri, S., Muñoz, O. (2009) Characterization of positional and configurational tropane alkaloid isomers by combining GC with NPD, MS and FTIR, Natural Product Communications 4, 1341-1348.
• Plantas medicinales del Jardin botánico de Asunción. Pin, A., Gonzalez, G., Marin, G., Céspedes, G., Cretton, S., Christen, P., Roguet, D., (Pin, A., Céspedes, G., Eds, Asunción, Paraguay, 2009. ISBN: 978-99953-2-166-6

2008¶

• Cuendet, M., Oteham, C.P., Craig, B.A., Moon, R.C., Pezzuto, J.M. (2008) Zapotin prevents mouse skin tumorigenesis during the stage of promotion, Anticancer Research, 28 (6A), 3705-3709.
• Cuendet, M., Oteham, C.P., Moon, R.C., Keller, W.J., Peaden, P.A., Pezzuto, J.M. (2008) Dietary administration of Asimina triloba (Paw Paw) extract increases tumor latency in N-methyl-N-nitrosourea-treated rats, Pharmaceutical Biology, 46 (1-2), 3-7.
• Humam, M., Christen, P., Muñoz, O., Hostettmann, K., Jeannerat, D. (2008) Absolute configuration of tropane alkaloids bearing two α,β-unsaturated ester functions using electronic CD spectroscopy. Application to (R,R)-trans-3-hydroxysenecioyloxy-6-senecioyloxytropane, Chirality 20, 20-25.
• Christen, P., Bieri, S., Veuthey, J.-L. (2008) Analysis of tropane alkaloids in biological matrices. In Modern Alkaloids. Fattorusso, E., Taglialatela-Scafati, O. eds., Wiley-VCH, Weinheim, Ger; pp. 341-367

2007¶

• Maiti, A., Cuendet, M., Endringer, D.C., Croy, V.L., Pezzuto, J.M., Cushman, M. (2007) Synthesis, SAR and biological evaluation of racemic abyssinone II and analogues as potential aromatase inhibitors for prevention of breast cancer, Journal of Medicinal Chemistry, 50 (12), 2799-2806.
• Maiti*, A., Cuendet*, M., Kondratyuk, T., Croy, V.L., Pezzuto, J.M., Cushman, M. (2007) Synthesis and Cancer Chemopreventive Activity of Zapotin, a Natural Product from Casimiroa edulis, Journal of Medicinal Chemistry, 50 (2), 350-355. * contributed equally to this work
• Kaufmann, B., Rudaz, S., Cherkaoui, S., Veuthey, J.-L., Christen, P. (2007) Influence of plant matrix on microwave-assisted extraction process. The case of diosgenin extracted from fenugreek (Trigonella foenum-graecum), Phytochemical Analysis 18, 70-76.
• Abdeljebbar, L.H., Humam, M., Christen, P., Jeannerat, D., Vitorge, B., Amzazi, S., Benjouad, A., Hostettmann, K., Bekkouche, K. (2007) Withanolides from Withania adpressa, Helvetica Chimica Acta 90, 346-352.
• Beejmohun, V., Fliniaux, O., Grand, E., Lamblin, F., Bensaddek, L., Christen, P., Kovensky, J., Fliniaux, M.-A., Mesnard, F. (2007) Microwave-assisted extraction of the main phenolic compounds in flaxseed, Phytochemical Analysis 18, 275-282.
• Humam M., Muñoz, O., Christen, P., Hostettmann, K. (2007) GC-MS analysis of the aerial parts of Schizanthus tricolor, Natural Product Communications 2, 743-747

2006¶

• Cuendet, M., Mesecar, A.D., DeWitt, D.L., Pezzuto, J.M. (2006) An ELISA method to measure inhibition of the COX enzymes, Nature Protocols, 1 (4), 1915-1921.
• Thole, J.M., Burns Kraft, T.F., Sueiro, L.A., Kang, Y.-H., Gills, J.J., Cuendet, M., Pezzuto, J.M., Seigler, D.S., Lila, M.A. (2006) A comparative evaluation of the anticancer properties of European and american elderberry fruits, Journal of Medicinal Food, 9 (4), 498-504.
• Cuendet, M., Bolton, J.L. (2006) Response of human mammary epithelial cells to DNA damage induced by 4-hydroxyequilenin: lack of p53-mediated G1 arrest, Chemico-Biological Interactions, 161 (3), 271-278.
• Cuendet, M., Oteham, C.P., Moon, R.C., Pezzuto, J.M. (2006) Quinone reductase induction as a biomarker for cancer chemoprevention, Journal of Natural Products, 69 (3), 460-463. 
• Cuendet, M., Pezzuto, J.M. (2006) Antitumor alkaloids in clinical use or in clinical trials. In Modern Alkaloids-Structure, Isolation, Synthesis and Biology. Fattorusso, E., Taglialatela-Scafati, O., eds. Wiley-VCH, Hoboken, NJ; pp. 25-52.
• Bieri, S., Muñoz, O., Veuthey, J.-L., Christen, P. (2006) Analysis of isomeric tropane alkaloids from Schizanthus grahamii by very fast gas chromatography, Journal of Separation Science 29, 96-102.
• Bieri, S., Brachet, A., Veuthey, J.-L., Christen, P. (2006) Cocaine distribution in wild Erythroxylum species, Journal of Ethnopharmacology 103, 439-447.
• Bieri, S., Varesio, E., Muñoz, O., Veuthey, J.-L., Christen, P. (2006) Use of porous graphitic carbon column for the separation of natural isomeric tropane alkaloids by capillary LC and mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis 40, 545-551.
• Jordan, M., Humam, M., Bieri, S., Christen, P., Poblete, E., Muñoz, O. (2006) In vitro shoot and root organogenesis, plant regeneration and production of tropane alkaloids in some species of Schizanthus, Phytochemistry 67, 570-578.
• Bieri, S., Varesio, E., Veuthey, J.-L., Muñoz, O., Tseng, L.-H., Braumann, U., Spraul, M., Christen, P. (2006) Identification of isomeric tropane alkaloids from Schizanthus grahamii by LC-NMR with loop storage and LC-UV/MS-SPE-NMR using a cryogenic flow probe, Phytochemical Analysis 17, 78-86.
• Bieri, S., Ilias, Y., Bicchi, C., Veuthey, J.-L., Christen, P. (2006) Focused microwave-assisted extraction combined with solid-phase microextraction and GC-MS for the selective analysis of cocaine from coca leaves, Journal of Chromatography A 1112, 127-132.
• Ilias, Y., Rudaz, S., Christen, P., Veuthey, J.-L. (2006) Cannabis profiling: Which analytical strategy to apply? Chimia 60, 290.
• Ilias, Y., Bieri, S., Christen, P., Veuthey, J.-L. (2006) Evaluation of solid-phase microextraction desorption parameters for fast-GC analysis of cocaine in coca leaves, Journal of Chromatographic Science 44, 394-398.
• Rubiolo, P., Matteodo, M., Riccio, G., Ballero, M., Christen, P., Fleury-Souverain, S., Veuthey, J.-L. Bicchi, C. (2006) Analytical discrimination of poisonous and non poisonous chemotypes of giant fennel (Ferula communis L.) through their biologically active and volatile fractions, Journal of Agricultural and Food Chemistry 54, 7556-7563.
• Ilias, Y., Rudaz, S., Christen, P., Veuthey, J.-L. (2006) Headspace solid-phase microextraction of pesticide residues in Cannabis samples, Chimia 60, 846-851

2005¶

• Overk, C.R., Yao, P., Chadwick, L.R., Nikolic, D., Sun, Y., Cuendet, M., Deng, Y., Hedayat, A.S., Pauli, G., Farnsworth, N.R., van Breeman, R.B., Bolton, J.L. (2005) Comparison of the in vitro estrogenic activities of hops (Humulus lupulus) and red clover (Trifolium pratense), Journal of Agricultural and Food Chemistry, 53 (16), 6246-6253.
• Carcache-Blanco, E.J., Cuendet, M., Park, E.J., Su, B.-N., Rivero-Cruz, J.F., Farnsworth, N.R., Pezzuto, J.M., Kinghorn, A.D. (2005) Potential cancer chemopreventive agents from Arbutus unedo, Natural Product Research, 20 (4), 327-334.
• Burns Kraft, T.F., Schmidt, B.M., Knight, C.T.G., Cuendet, M., Gills, J.J., Kang, Y.-H., Pezzuto, J.M., Seigler, D.S., Lila, M.A. (2005) Chemopreventive potential of wild lowbush blueberry fruits in multiple stages of carcinogenesis, Journal of Food Science, 70 (3), S159-S166. 
• Pezzuto, J.M., Kosmeder II, J.W., Park, E.J., Lee, S.K., Cuendet, M., Gills, J., Bhat, K., Grubjesic, S., Park, H.-S., Mata-Greenwood, E., Tan, Y.M., Yu, R., Lantvit, D.D., Kinghorn, A.D. (2005) Characterization of chemopreventive agents in natural products. In Cancer Chemoprevention, Volume 2: Strategies for Cancer Chemoprevention. Kelloff, G.J., Hawk, E.T., Sigman, C.C., eds. Humana Press Inc., Totowa, NJ; pp. 3-37.
• Brock, A., Bieri, S., Christen, P., Dräger, B. (2005) Calystegines in wild and cultivated Erythroxylum species, Phytochemistry 66, 1231-1240.
• Humam M., Bieri, S., Geiser, L., Muñoz, O., Veuthey, J.-L., Christen, P. (2005) Separation of four isomeric tropane alkaloids from Schizanthus grahamii by nonaqueous capillary electrophoresis, Phytochemical Analysis 16, 349-356.
• Ilias, Y., Rudaz, S., Mathieu, P., Christen, P., Veuthey, J.-L. (2005) Extraction and analysis of different Cannabis samples by headspace solid-phase microextraction combined with gas chromatography – mass spectrometry, Journal of Separation Science 28, 2293-2300

2004¶

• Su, B.-N., Jones, W., Cuendet, M., Kardono, L.B.S., Ismail, R., Riswan, S., Fong, H.H.S., Farnsworth, N.R., Pezzuto, J.M., Kinghorn, A.D. (2004) Constituents of the stems of Macrococculus pomiferus and their inhibitory activities against cyclooxygenases-1 and -2, Phytochemistry, 65 (21), 2861-2866.
• Gafner, S., Lee, S.K., Cuendet, M., Barthélémy, S., Vergnes, L., Labidalle, S., Mehta, R.G., Boone, C.W., Pezzuto, J.M. (2004) Biologic evaluation of curcumin and structural derivatives in cancer chemoprevention model systems, Phytochemistry, 65 (21), 2849-2859.
• Li, Y., Yao, J., Chang, M., Cuendet, M., Bolton, J.L. (2004) Altered apoptotic response in MCF 10A cells treated with the equine estrogen metabolite, 4-hydroxyequilenin, Toxicology Letters, 154 (3), 225-233.
• Jang, D.S., Cuendet, M., Su, B.-N., Tortura, S., Riswan, S., Fong, H.H.S., Pezzuto, J.M., Kinghorn, A.D. (2004) Constituents of the seeds of Hernandia ovigera with inhibitory activity against cyclooxygenase-2, Planta Medica, 70 (10), 893-896.
• Kinghorn, A.D., Su, B.N., Jang, D.S., Chang, L.C., Lee, D., Gu, J.Q., Carcache-Blanco, E.J., Pawlus, A.D., Lee, S.K., Park, E.J., Cuendet, M., Gills, J.J., Bhat, K., Park, H.S., Mata-Greenwood, E., Song, L.L., Jang, M., Pezzuto, J.M. (2004) Natural inhibitors of carcinogenesis, Planta Medica, 70 (8), 691-705.
• Cuendet, M., Liu, X., Pisha, E., Li, Y., Yao, J., Yu, L., Bolton, J.L. (2004) Equine estrogen metabolite 4-hydroxyequilenin induces anchorage-independent growth of human mammary epithelial MCF-10A cells: differential gene expression, Mutation Research, 550 (1-2), 109-121.
• Jang, D.S., Cuendet, M., Fong, H.H.S., Pezzuto, J.M., Kinghorn, A.D. (2004) Constituents of Asparagus officinalis (Asparagus) evaluated for inhibitory activity against cyclooxygenase-2, Journal of Agricultural and Food Chemistry, 52 (8), 2218-2222.
• Cuendet, M., Pezzuto, J.M. (2004) Antitumor activity of bruceantin: an old drug with new promise, Journal of Natural Products, 67 (2), 269-272.
• Cuendet, M., Gills, J.J., Pezzuto, J.M. (2004) Brusatol-induced HL-60 cell differentiation involves NF-κB activation, Cancer Letters, 206 (1), 43-50.
• Cuendet, M., Christov, K., Lantvit, D.D., Deng, Y., Hedayat, S., Helson, L., McChesney, J.D., Pezzuto, J.M. (2004) Multiple myeloma regression mediated by bruceantin, Clinical Cancer Research, 10 (3), 1170-1179.
• Jang, D.S., Cuendet, M., Pawlus, A., Kardono, L.B.S., Kawanisi, K., Farnsworth, N.R., Fong, H.H.S., Pezzuto, J.M., Kinghorn, A.D. (2004) Potential cancer chemopreventive constituents of the leaves of Macaranga triloba, Phytochemistry, 65 (3), 345-350.
• Bieri, S., Christen, P., Biedermann, M., Grob, K. (2004) Inability of unpacked gooseneck liners to stop the sample liquid after injection with band formation (fast autosampler) into hot GC injectors, Analytical Chemistry 76, 1696-1701.
• Ilias, Y., Rudaz, S., Mathieu, P., Veuthey, J.-L., Christen, P. (2004) Analysis of cannabis material by headspace solid-phase microextraction combined with gas chromatography-mass spectrometry, Chimia 58, 219-221.
• Lanoue, A., Shakourzadeh, K., Marison, I., Laberche, J.-C., Christen, P., Sangwan-Norreel, B., Boitel-Conti, M. (2004) Occurrence of circadian rhythms in hairy root cultures grown under controlled conditions, Biotechnology & Bioengineering 88, 722-729.
• Lanoue, A., Boitel-Conti, Dechaux, C., Laberche, J.-C., Christen, P., Sangwan-Norreel, B. (2004) Comparison of growth properties, alkaloid production and water uptake of two selected Datura hairy root lines, Acta Biologica Cracoviensia Series Botanica 46, 185-192

2003¶

• Su, B.-N., Cuendet, M., Nikolic, D., Kristinsson, H., Ingólfsdóttir, K., van Breemen, R.B., Fong, H.H.S., Pezzuto, J.M., Kinghorn, A.D. (2003) NMR study of fumarprotocetratic acid, a complex lichen depsidone derivative from Cladonia furcata, Magnetic Resonance in Chemistry, 41 (5), 391-394.
• Duncan, C.J.G., Cuendet, M., Fronczek, F.R., Pezzuto, J.M., Mehta, R.G., Hamman, M.T., Ross, S.A. (2003) Chemical and biological investigation of the fungus Pulveroboletus ravenelii, Journal of Natural Products, 66 (1), 103-107

2002¶

• Jang, D.S., Cuendet, M., Hawthorne, M.E., Kardono, L.B.S., Kawanishi, K., Fong, H.H.S., Mehta, R.G., Pezzuto, J.M., Kinghorn, A.D. (2002) Prenylated flavonoids of the leaves of Macaranga conifera with activity against cyclooxygenase-2, Phytochemistry, 61 (7), 867-872.
• Su, B.-N., Cuendet, M., Farnsworth, N.R., Fong, H.H.S., Pezzuto, J.M., Kinghorn, A.D. (2002) Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay, Planta medica, 68 (12), 1125-1128.
• Mata-Greenwood*, E., Cuendet*, M., Sher, D., Gustin, D., Stock, W., Pezzuto, J.M. (2002) Brusatol-mediated induction of leukemic cell differentiation and G1 arrest is associated with down-regulation of c-myc, Leukemia, 16 (11), 2275-2284.

* contributed equally to this work

• Su, B.-N., Chang, L.C., Park, E.J., Cuendet, M., Santarsiero, B.D., Mesecar, A.D., Meha, R.G., Fong, H.H.S., Pezzuto, J.M., Kinghorn, A.D. (2002) Bioactive constituents of the seeds of Brucea javanica, Planta Medica, 68 (8), 730-733.
• Cuendet, M., Pezzuto, J.M. (2002) Non-steroidal anti-inflammatory drugs in cancer treatment, Expert Opinion on Therapeutic Patents, 12 (6), 827-835.
• Rimando, A.M., Cuendet, M., Desmarchelier, C., Mehta, R.G., Pezzuto, J.M., Duke, S.O. (2002) Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol, Journal of Agricultural and Food Chemistry, 50 (12), 3453-3457.
• Su, B.-N., Cuendet, M., Hawthorne, M.E., Kardono, L.B.S., Riswan, S., Fong, H.H.S., Meha, R.G., Pezzuto, J.M., Kinghorn, A.D. (2002) Constituents of the barks and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity, Journal of Natural Products 65 (2), 163-169.
• Kaufmann, B., Christen, P. (2002) Recent extraction techniques for natural products: microwave-assisted extraction and pressurised solvent extraction, Phytochemical Analysis 13, 105-113.
• Brachet, A., Christen, P., Veuthey, J.-L. (2002) Focused microwave-assisted extraction of cocaine and benzoylecgonine from coca leaves, Phytochemical Analysis 13, 162-169.
• Christen, P. (2002) Trigonella species: In vitro culture and production of secondary metabolites. In Biotechnology in Agriculture and Forestry. Nagata, T., Ebizuka, Y. eds. Vol. 51, Springer Verlag, Berlin, Ger; pp. 306-327.
• Kaufmann, B., Souverain, S., Cherkaoui, S., Christen, P., Veuthey, J.-L. (2002) Rapid liquid chromatographic-mass spectrometric analysis of withanolides in crude plant extracts by use of a monolithic column, Chromatographia 56, 137-141.
• Lanoue, A., Boitel-Conti, M., Portais, J.-C., Laberche, J.-C., Barbotin, J.-N., Christen, P., Sangwan-Norreel, B. (2002) Kinetic study of littorine rearrangement in Datura innoxia hairy roots by 13C NMR spectroscopy, Journal of Natural Products 65, 1131-1135

2001¶

• Waffo-Teguo, P., Hawthorne, M.E., Cuendet, M., Mérillon, J.-M., Kinghorn, A.D., Pezzuto, J.M., Mehta, R.G. (2001) Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures, Nutrition and Cancer, 40 (2), 173-179.
• Lee, D., Cuendet, M., Axelrod, F., Chavez, P.I., Fong, H.H.S., Pezzuto, J.M., Kinghorn, A.D. (2001) Novel 29-nor-3,4-seco-cycloartane triterpene methyl esters from the aerial parts of Antirhea acutata, Tetrahedron, 57 (33), 7107-7112.
• Lee, D., Cuendet, M., Vigo, J.S., Graham, J.G., Cabieses, F., Fong, H.H.S., Pezzuto, J.M., Kinghorn, A.D. (2001) A novel cyclooxygenase-inhibitory stilbenolignan from the seeds of Aiphanes aculeata, Organic Letters, 3 (14), 2169-2171.
• Lee, D., Park, E.J., Cuendet, M., Axelrod, F., Chavez, P.I., Fong, H.H.S., Pezzuto, J.M., Kinghorn, A.D. (2001) Cyclooxygenase-inhibitory and antioxidant constituents of the aerial parts of Antirhea acutata, Bioorganic and Medicinal Chemistry Letters, 11 (12),1565-1568.
• Waffo-Teguo, P., Lee, D., Cuendet, M., Mérillon, J.-M., Pezzuto, J.M., Kinghorn, A.D. (2001) Two new stilbene dimer glucosides from grape (Vitis vinifera) cell cultures, Journal of Natural Products, 64 (1), 136-138.
• Cuendet, M., Potterat, O., Hostettmann, K. (2001) Flavonoids and phenylpropanoid derivatives from Campanula barbata, Pytochemistry, 56 (6), 631-636.
• Cherkaoui, S., Bekkouche, K., Christen, P., Veuthey, J.-L. (2001) Non-aqueous capillary electrophoresis with diode array and electrospray mass spectrometric detection for the analysis of selected steroidal alkaloids in plant extracts, Journal of Chromatography A 922, 321-328.
• Bekkouche, K., Daali, Y., Cherkaoui, S., Veuthey, J.-L. Christen, P. (2001) Calystegine distribution in some solanaceous species, Phytochemistry 58, 455-462.
• Kaufmann, B., Christen, P., Veuthey, J.-L. (2001) Parameters affecting microwave-assisted extraction of withanolides, Phytochemical Analysis 12, 327-331.
• Penelle, J., Christen, P., Molgo, J., Tits, M., Brandt, V., Frédérich, M., Angenot, L. (2001) 5'6'-dehydroguiachrysine and 5',6'-dehydroguiaflavine, two curarizing quaternary indole alkaloids from the stem bark of Strychnos guianensis, Phytochemistry 58, 619-626.
• Kaufmann, B., Christen, P., Veuthey, J.-L. (2001) Study of factors influencing pressurised solvent extraction of polar steroids from plant material. Application to the recovery of withanolides, Chromatographia 54, 394-398.
• Christen, P., Veuthey, J.-L. (2001) New trends in extraction, identification and quantification of artemisinin and its derivatives, Current Medicinal Chemistry 8, 1827-1839.
• Brachet, A., Rudaz, S., Mateus, L., Christen, P., Veuthey, J.-L. (2001) Optimisation of accelerated solvent extraction of cocaine and benzoylecgonine from coca leaves, Journal of Separation Science 24, 865-873

2000¶

• Cuendet, M., Pezzuto, J.M. (2000) The role of cyclooxygenase and lipoxygenase in cancer chemoprevention, Drug Metabolism and Drug Interactions, 17, 109-157.
• Cuendet, M., Potterat, O., Hostettmann, K. (2000) A stilbene and dihydrochalcones with radical scavenging activities from Loiseleuria procumbens, Phytochemistry, 54 (8), 871-874.
• Brunner, G., Bürger, U., Castioni, P., Kapétanidis, I., Christen, P. (2000) A novel acylated flavonol glycoside isolated from Brunfelsia grandiflora ssp. grandiflora. Structure elucidation by gradient accelerated NMR spectroscopy at 14 T, Phytochemical Analysis 11, 29-33.
• Kohler, M., Haerdi, W., Christen, P., Veuthey, J.-L. (2000) Determination of artemisinin in Artemisia annua L. by supercritical fluid chromatography coupled to an evaporative light scattering detector. In Supercritical Fluid Methods and Protocols. Williams, J.R., Clifford, A.A. eds. Vol. 13, Humana Press, Totowa, USA; pp. 135-143.
• Christen, P. (2000) Tropane alkaloids : Old drugs used in modern medicine. In Studies in Natural Products Chemistry. Rahman, A. U. ed. Vol. 22, Elsevier, Amsterdam, NL; pp. 717-749.
• Mateus, L., Cherkaoui, S., Christen, P., Veuthey, J.-L. (2000) Enantioseparation of atropine by capillary electrophoresis using sulfated -cyclodextrin: application to a plant extract, Journal of Chromatography A 868, 285-294.
• Penelle, J., Tits, M., Christen, P., Molgo, J., Brandt, V., Frédérich, M., Angenot, L. (2000) Quaternary indole alkaloids from the stem bark of Strychnos guianensis, Phytochemistry 53, 1057-1066.
• Mateus, L., Cherkaoui, S., Christen, P., Oksman-Caldentey, K.-M. (2000) Simultaneous determination of scopolamine, hyoscyamine and littorine in plants and different hairy root clones of Hyoscyamus muticus by micellar electrokinetic chromatography, Phytochemistry 54, 517-523.
• Brachet, A., Christen, P., Gauvrit, J.-Y., Longeray, R., Lantéri, P., Veuthey, J.-L. (2000) Experimental design in supercritical fluid extraction of cocaine from coca leaves, Journal of Biochemical and Biophysical Methods 43, 353-366.
• Daali, Y., Bekkouche, K., Cherkaoui, S., Christen, P., Veuthey, J.-L. (2000) Use of borate complexation for the separation of non UV-absorbing calystegines by capillary electrophoresis, Journal of Chromatography A 903, 237-244

1999¶

• Cuendet, M., Potterat, O., Hostettmann, K. (1999) Iridoid glucosides, phenylpropanoid derivatives and flavonoids from Bartsia alpina, Pharmaceutical Biology, 37 (4), 318-320.
• Cherkaoui, S., Mateus, L., Christen, P., Veuthey, J.-L. (1999) Non Aqueous Capillary Electrophoresis for the Analysis of Selected Tropane Alkaloids in Plant Extract, Chromatographia 49, 54-60.
• Penelle, J., Tits, M., Christen, P., Brandt, V., Frédérich, M., Angenot, L. (1999) Guiaflavine, a new bisindole quaternary alkaloid from the stem bark of Strychnos guianensis, Journal of Natural Products 62, 898-900.
• Christen, P (1999) Centranthus Species : In vitro culture, and the production of valepotriates and other secondary metabolites. In Biotechnology in Agriculture and Forestry. Bajaj, Y.P.S. ed. Vol 43, Springer Verlag, Berlin, Ger; pp. 42-56.
• Cherkaoui, S., Mateus, L., Christen, P., Veuthey, J.-L. (1999) Nonaqueous versus aqueous capillary electrophoresis for the dosage of N-butylscopolamine in various pharmaceutical formulations, Journal of Pharmaceutical and Biomedical Analysis 21, 165-174.
• Mateus, L., Cherkaoui, S., Christen, P., Veuthey, J.-L. (1999) Capillary electrophoresis-diode array detection-electrospray mass spectrometry for the analysis of selected tropane alkaloids in plant extracts, Electrophoresis 20, 3402-3409.
• Daali, Y., Cherkaoui, S., Christen, P., Veuthey, J.-L (1999) Experimental design for enantioselective separation of celiprolol by capillary electrophoresis using sulfated -cyclodextrin, Electrophoresis 20, 3424-3431.
• Brachet, A., Mateus, L., Cherkaoui, S., Christen, P., Gauvrit, J.-Y., Lantéri, P., Veuthey, J.-L. (1999) Application of central composite designs in the supercritical fluid extraction of tropane alkaloids in plant extracts, Analusis 27, 772-778.
• Mateus, L., Cherkaoui, S., Christen, P., Veuthey, J.-L. (1999) Application of a micellar electrokinetic chromatography to the determination of some tropane alkaloids in various plant extracts, Current Topics in Phytochemistry 2, 175-182

1998¶

• Nussbaumer, P., Kapétanidis, I., Christen, P. (1998) Hairy roots of Datura candida x Datura aurea. Effect of culture medium composition on growth and alkaloid biosynthesis, Plant Cell Reports 17, 405-409.
• Cherkaoui, S., Varesio, E., Christen, P., Veuthey, J.-L. (1998) Selectivity manipulation using non aqueous capillary electrophoresis. Application to tropane alkaloids and amphetamine derivatives, Electrophoresis 19, 2900-2906.
• Cherkaoui, S., Mateus, L., Christen, P., Veuthey, J.-L. (1998) Validated capillary electrophoresis method for the determination of atropine and scopolamine derivatives in pharmaceutical formulations, Journal of Pharmaceutical and Biomedical Analysis 17, 1167-1176.
• Cherkaoui, S., Daali, Y., Christen, P., Veuthey, J.-L. (1998) Development and validation of liquid chromatography and capillary electrophoresis methods for acarbose determination in pharmaceutical tablets, Journal of Pharmaceutical and Biomedical Analysis 18, 729-735.
• Mateus, L., Cherkaoui, S., Christen, P., Veuthey, J.-L. (1998) Capillary electrophoresis for the analysis of tropane alkaloids: pharmaceutical and phytochemical applications, Journal of Pharmaceutical and Biomedical Analysis 18, 815-825.
• Cherkaoui, S., Mateus, L., Christen, P., Veuthey, J.-L. (1998) Use of a Doehlert design in optimizing the analysis of selected tropane alkaloids by micellar electrokinetic capillary chromatography, Journal of Chromatography A 829, 317-325

1997¶

• Cuendet, M., Hostettmann, K., Dyatmiko, W., Potterat, O. (1997) Iridoid glucosides with free radical scavenging properties from Fagraea blumei, Helvetica Chimica Acta, 80 (4), 1144-1152.
• Kohler, M., Haerdi, W., Christen, P., Veuthey, J.-L. (1997) Determination of artemisinin and artemisinic acid by capillary and packed supercritical fluid chromatography, Journal of High Resolution Chromatography 20, 62-66.
• Kohler, M., Haerdi, W., Christen, P., Veuthey, J.-L. (1997) Extraction of artemisinin and artemisinic acid from Artemisia annua L. using supercritical carbon dioxide, Journal of Chromatography A 785, 353-360.
• Brachet, A., Muñoz, O., Gupta, M., Veuthey, J.-L., Christen, P. (1997) Alkaloids of Erythroxylum lucidum stem-bark, Phytochemistry 46, 1439-1442.
• Cherkaoui, S., Mateus, L., Christen, P., Veuthey, J.-L. (1997) Development and validation of a capillary zone electrophoresis method for the determination of atropine, homatropine and scopolamine in ophtalmic solutions, Journal of Chromatography B 696, 283-290.
• Kohler, M., Haerdi, W., Christen, P., Veuthey, J.-L. (1997) SFE and SFC of artemisinin and artemisinic acid. An improved method for the analysis of Artemisia annua samples, Phytochemical Analysis 8, 223-227.
• Kohler, M., Haerdi, W., Christen, P., Veuthey, J.-L. (1997) The evaporative light scattering detector: some applications in pharmaceutical analysis, Trends in Analytical Chemistry 16, 475-484.
• Veuthey, J.-L., Christen, P. (1997) What type of research is done in the Laboratory of Pharmaceutical Analytical Chemistry of the University of Geneva?, Chimia 51, 795-797.
• Cherkaoui, S., Mateus, L., Christen, P., Veuthey, J.-L. (1997) Micellar electrokinetic capillary chromatography for selected tropane alkaloid analysis in plant extract, Chromatographia 46, 351-357,

1996¶

• Merkli, A., Christen, P., Kapétanidis, I. (1996) Production of diosgenin by hairy root cultures of Trigonella foenum-graecum L., Plant Cell Reports 16, 632-636

1995¶

• Gränicher, F., Christen, P., Kapétanidis, I. (1995) Production of valepotriates by hairy root cultures of Centranthus ruber DC, Plant Cell Reports 14, 294-298.
• Gränicher, F., Christen, P., Kalamaprija, P., Bürger, U. (1995) An iridoid diester from Valeriana officinalis var. sambucifolia hairy roots, Phytochemistry 38, 103-105.
• Christen, P., Roberts, M.F., Phillipson, J.D., Evans W.C. (1995) Alkaloids of Erythroxylum monogynum root-bark, Phytochemistry 38, 1053-1056.
• Castioni, P., Christen, P., Veuthey, J.-L. (1995) L'extraction en phase supercritique des substances d'origine végétale, Analusis 23, 95-106.
• Gränicher, F., Christen, P. (1995) Valeriana species: In vitro culture and the formation of sesquiterpenes and valepotriates. In Biotechnology in Agriculture and Forestry. Bajaj, Y.P.S. ed. Vol 33, Springer Verlag, Berlin, Ger; pp. 442-458.
• Gränicher, F., Christen, P., Kapétanidis I. (1995) Essential oils from normal and hairy roots of Valeriana officinalis var. sambucifolia, Phytochemistry 40, 1421-1424

1994¶

• Dupraz, J.-M., Christen, P., Kapétanidis, I. (1994) Tropane alkaloids in transformed roots of Datura quercifolia, Planta Medica 60, 158-162.
• Gränicher, F., Christen, P., Vuagnat, P. (1994) Rapid high performance liquid chromatographic quantification of valepotriates in hairy root cultures of Valeriana officinalis L. var. sambucifolia Mikan, Phytochemical Analysis 5, 297-301

1993¶

• Christen, P., Roberts, M.F. (1993) Transformation in Datura. In Biotechnology in Agriculture and Forestry. Bajaj, Y.P.S. ed. Springer Verlag, Berlin, Ger; Vol 22, pp. 157-171.
• Christen, P., Roberts, M.F., Phillipson, J.D., Evans W.C. (1993) Alkaloids of Erythroxylum zambesiacum stem-bark, Phytochemistry 34, 1147-1151

1992¶

• Gränicher, F., Christen, P., Kapétanidis, I. (1992) High-yield production of valepotriates by hairy root cultures of Valeriana officinalis var. sambucifolia Mikan, Plant Cell Reports 11, 339-342.
• Christen, P., Aoki, T., Shimomura, K. (1992) Characteristics of growth and tropane alkaloid production in Hyoscyamus albus hairy roots transformed with Agrobacterium rhizogenes A4, Plant Cell Reports 11, 597-600

1991¶

• Gander, B., Kloeti, F., Christen, P. (1991) Stability of corticosteroids in zinc oxide-containing hydrophilic paste and lipophilic ointment, European Journal of Pharmaceutics and Biopharmaceutics 37, 64-68.
• Christen, P. (1991) Production de métabolites secondaires par culture de racines génétiquement transformées, Cahier de la Faculté des Sciences No 22, 37-48

1990¶

• Christen, P., Roberts, M.F., Phillipson, J.D., Evans W.C. (1990) Alkaloids of hairy root cultures of a Datura candida hybrid, Plant Cell Reports 9**,** 101-104.
• Christen, P., Kloeti, F., Gander, B. (1990) Stability of prednisolone and prednisolone acetate in various vehicles used in semi-solid topical preparations, Journal of Clinical Pharmacy and Therapeutics 15, 325-329

1989¶

• Christen, P., Roberts, M.F., Phillipson, J.D., Evans W.C. (1989) High yield production of tropane alkaloids by hairy root cultures of a Datura candida hybrid, Plant Cell Reports 8, 75-77.
• Christen, P. (1989) Withanolide: Naturstoffe mit vielversprechendem Wirkungsspektrum, Pharmazie in unserer Zeit 18, 129-139

1988¶

• Christen, P., Kapétanidis, I. (1988) Isolation and characterization of a withanolide from the leaves of Lycium halimifolium Miller (Solanaceae), Pharmaceutica Acta Helvetiae 63, 263-265

1987¶

• Christen, P., Kapétanidis, I. (1987) Etude phytochimique des feuilles de Lycium halimifolium Miller (Solanaceae). 1ère partie. Recherche des alcaloïdes. Pharmaceutica Acta Helvetiae 62, 154-157.
• Christen, P., Kapétanidis, I. (1987) Etude phytochimique des feuilles de Lycium halimifolium Miller (Solanaceae). 2ème partie. Identification des constituants entraînables à la vapeur d'eau Pharmaceutica Acta Helvetiae 62, 158-162.
• Christen, P., Kapétanidis, I. (1987) Flavonoids from Lycium halimifolium, Planta Medica 53, 571-572

1986¶

• Christen P. (1986) Les withanolides, stéroïdes végétaux à structure originale, Pharmaceutica Acta Helvetiae 61, 242-246

1985¶

• Kloeti, F., Christen, P., Kapétanidis, I. (1985) Vorschlag befreffend zukünftiger Pharmakopöe-Forderungen für die Analyse von "Melissae folium", Fresenius Zeitschrift für Analytische Chemie 321, 352-354.