Cancer Systems Pharmacology

The overall aim of the Cancer Systems Pharmacology group’s research is to identify optimized therapeutic strategies for treating complex diseases, primarily cancer. Our approach integrates fundamental research to uncover the mechanisms of action of optimized drug combinations, employing a bedside-to-bench-and-back framework to personalize therapies within a clinically relevant timeframe. These findings may reveal novel signaling pathways, resistance mechanisms, and open new avenues for drug discovery.

We work in close collaboration with clinicians, engineers, biologists, and medical oncologists to conduct clinically relevant translational research. Our goal is to enhance cancer treatment efficacy, minimize side effects, and reduce the likelihood of acquired drug resistance.

Our ultimate goal is to develop personalized synergistic combination therapies to the dynamically changing tumor response.