Analyse pharmaceutique

Guillarme Lab - University of Geneva¶

Our research group pioneers innovative chromatographic strategies to advance the analytical characterization of next-generation therapeutics.¶

In our laboratory, we are developing innovative chromatographic strategies, based on various modes of liquid chromatography (RPLC, HILIC, SEC, IEX, HIC, IP-RPLC, Affinity-LC…), SFC, and 2D-LC, coupled or not with mass spectrometry. Our goal is to enhance throughput, automatization, selectivity, sensitivity, and peak capacity.

These advanced chromatographic methods are applied to the characterization of next-generation therapeutics, including monoclonal antibodies (mAbs), oligonucleotides, peptides, proteins, mRNA, recombinant adeno-associated viruses (rAAVs), and lipid nanoparticles.

We collaborate extensively with pharmaceutical companies to gain access to demanding samples that serve as benchmarks for our methodologies, as well as with instrumentation providers to gain access to cutting-edge systems and chromatographic columns for our research.