Ocular delivery

Improving drug bioavailability in the anterior and posterior segments¶

• A new research activity concerns investigation into methods to improve drug delivery to the eye.
• Particular emphasis has been on the combination of short duration ocular iontophoresis with prodrug conjugates possessing physicochemical properties that favour their electrotransport into the eye.
• We are interested in both corneal iontophoresis and transscleral iontophoresis, which enables the posterior segment to be reached.
• Again, a new experimental set-up, involving use of the whole eye globe, enables evaluation of drug bioavailability in the different ocular compartments.