Biophysical and Bioanalytical Mass Spectrometry

Our team develops advanced mass spectrometry methods for biophysics (folding, drug-target interaction) and biomolecule analysis, especially nucleic acids.¶

Our develops new mass spectrometry tools to study the drug regulation of gene expression. One of our historic specialties is “native” mass spectrometry (the study of non-covalent interactions by mass spectrometry) of nucleic acids structures and their complexes. The group at UNIGE will expand this scope towards integrating MS with other drug-target biophysical analysis methods, characterizing novel classes of therapeutics, and extending the omics approaches to the top-down analysis of RNA modifications. Although rooted in analytical chemistry, our work is multi-disciplinary, spanning from fundamental research (molecular recognition, manipulating isolated ions in the mass spectrometer) to biological and biomedical sciences (drug design and screening, biophysics, biological therapeutics).

Learn more about our research, our instruments, and the team