From mass spectra to molecular thermodynamics¶

Our research addresses a fundamental question: how does molecular information survive—and transform—when a biomolecule moves from solution into the mass spectrometer, and how to exploit this information? We combine mass spectrometry, ion mobility, ion spectroscopy, controlled activation and quantitative modelling to understand this transfer and turn it into useful molecular information.

We apply these approaches to nucleic acids and their interactions with proteins, ligands and therapeutic molecules, with particular interest in structure, energetics, thermodynamics and kinetics. At the same time, we develop new ways to interpret ion signals, collision cross sections and fragmentation as physical observables rather than empirical fingerprints.

Our ambition is to make mass spectrometry a quantitative tool for molecular biophysics.

Learn more about our research, our instruments, and the team