Biophysical and Bioanalytical Mass Spectrometry


Our team develops advanced mass spectrometry methods for biophysics (folding, drug-target interaction) and biomolecule analysis, especially nucleic acids.

One of our historic specialties is “native” mass spectrometry (the study of non-covalent interactions by mass spectrometry) of nucleic acids structures and their complexes. The group at UNIGE will expand this scope towards integrating MS with other drug-target biophysical analysis methods, characterizing novel classes of therapeutics, and extending the omics approaches to the top-down analysis of RNA modifications. Although rooted in analytical chemistry, our work is multi-disciplinary, spanning from fundamental research (molecular recognition, manipulating isolated ions in the mass spectrometer) to biological and biomedical sciences (drug design and screening, biophysics, biological therapeutics).