Université de Genève

Section of Pharmaceutical Sciences Molecular therapeutics delivery group

ISPSO

Analytics

Drugs in formulations and in drug delivery experiments need to be quantified by specific, sensitive and robust analytical arsenal:


> HPLC-UV-Fluo and HPLC-Ion chromatography

High pressure liquid chromatography ensures accurate and precise quantification of lipophilic and polar, neutral and ionized drugs in formulation and in vitro experiment samples: the typical limits of quantification are of 5 μg/ml.

Chromatic separation and identification of TRN isomers

> UHPLC-UV

Ultra High pressure liquid chromatography ensures accurate and precise quantification of lipophilic and polar, neutral and ionized drugs in formulation and in vitro experiment samples: the typical limits of quantification are of 5 μg/ml. Moreover the chromatographic system is miniaturized leading to short analysis times and thus high throughput analyses.

UPLC-MS/MS

> UHPLC-MS/MS

UHPLC-MS/MS combines the advantages of UHPLC and the cutting edge tandem mass detection with the ability to detect the analytes selectively in complex matrixes and with ultra-high sensitivity: : the typical limits of quantification are of 5 ng/ml.

MRM scan of testosterone

> Flash chromatography

Flash chromatography is a preparative HPLC system used to purifiy reaction mixtures during the prodrug synthesis activities.

> Immunoassays

Proteic drugs that cannot undergo chromatography are often quantified using immunoassay provided as kits or developed in house.