Biochimie pharmaceutique

Mission¶

Our research focuses on molecular recognition for a better understanding of ligand-macromolecule interactions in order to develop new therapeutic strategies including new chemical entities and new targets, using an interdisciplinary approach based on the combination of biochemistry/biophysics and chemistry with computational chemistry/molecular modelling.¶

The research in the field of pharmaceutical biochemistry/chemistry covers three main topics, namely Cancer, Neglected Diseases, Rare Diseases and Antibiotics Research.

• In Cancer Research we have two main objectives, namely the development of a thymidine kinase based safety and monitoring tool for stem cells therapy and the development of inhibitors of the tyrosine kinase domain of oncogenic fusion proteins involved in signalling pathways.
• Within the research area of Neglected Diseases and Rare Diseases we aim at elucidating and validating new potential drug targets for developing therapeutic strategies against orphan diseases e.g. dystrophy/SMA and the major parasitic diseases of the Third World e.g. Malaria, Tripanosomiasis and Leishmaniosis as well as finding potential lead compounds against such diseases.
• Within the area of Antibiotic Research the objective is to find compounds inhibiting bacterial virulence with novel mechanisms of action.

Research Technologies and competences¶

Research projects¶